Quarterly EJEM research round-up - June 2024

Welcome to the quarterly EJEM research round-up, where we present our top picks from the last three months of EJEM editions.

Chiara Lazzeri, Associate Editor

Verdonschot et al [1]performed a retrospective two-centre study to investigate the number of in-hospital cardiac arrest (IHCA) and out-of-hospital cardiac arrest (OHCA) patients eligible to Extracorporeal Cardiopulmonary Resuscitation (ECPR). Clinical characteristics that may help to identify which patients benefit the most from ECPR were also detected. The study population comprised all IHCA and OHCA patients screened for eCPR between 1 January 2017 and 1 January 2020 in Rotterdam, the Netherlands. The features of this investigation are the large population included and the organizational characteristics of the Netherlands. This country, small and densly populated, is characterized by a short travel time to the hospital and the existence of is a nationwide response system exists that alerts trained citizens when an OHCA occurs in their neighbourhood. That is probably why in Netherlands the use of Automated External Defibrillator (AED) (29-65%) is higher than in other countries....

Read more...

NEW PUBLICATION: RECOMMENDATIONS FOR BLOOD SAMPLING IN EMERGENCY DEPARTMENTS

From the journal Clinical Chemistry and Laboratory Medicine (CCLM).

ABSTRACT

Blood Sampling Guidelines have been developed to target European emergency medicine-related professionals involved in the blood sampling process (e.g. physicians, nurses, phlebotomists working in the ED), as well as laboratory physicians and other related professionals. The guidelines population focus on adult patients. The development of these blood sampling guidelines for the ED setting is based on the collaboration of three European scientific societies that have a role to play in the preanalytical phase process: EuSEN, EFLM, and EUSEM. The elaboration of the questions was done using the PICO procedure, literature search and appraisal was based on the GRADE methodology. The final recommendations were reviewed by an international multidisciplinary external review group. Continue reading

 

 

 

This study was conducted in a joint collaboration between EuSEN, EFLM, and EUSEM.

 

 

Read more...

Temperature control after successful resuscitation from cardiac arrest in adults: a joint statement by EUSEM and ESAIC

Background: Out-of-hospital cardiac arrest (OHCA) is the third leading cause of death in Europe, with a high burden of disability for patients and their families [1]. When the heart stops, the body and brain cells quickly deplete of oxygen. Without intervention, brain damage occurs rapidly, and death is inevitable. Unfortunately, the prognosis for OHCA patients remains poor, even when return of spontaneous circulation (ROSC) is achieved. Only a few (less than 10%) of OHCA patients can be discharged from the hospital, and only two-thirds of these are discharged with a good neurologic outcome to lead an independent life [1].

Reperfusion injury starts immediately following ROSC. Multiple pathophysiologic cascades lead to reactive astrogliosis and microglia activation and neuronal death by necrosis and apoptosis. This is one of the key component of what has been described as ‘post-resuscitation syndrome’ [2]. Mild hypothermia in the temperature range of 32 to 34°C was shown to mitigate these different pathophysiologic cascades simultaneously, efficiently limiting brain cell damage [3]. Numerous animal studies confirmed the beneficial effect of mild hypothermia [4]. In 2002, two landmark randomized clinical trials (RCT) in patients after cardiac arrest with shockable rhythm showed improved neurological outcomes following treatment with mild hypothermia in the range of 32 to 34°C compared to no temperature control [5,6]. As a result of these studies, in 2005, the European Resuscitation Council (ERC) guidelines recommended the use of mild hypothermia in the range of 32 to 34°C for 24 h in unconscious adults resuscitated following out-of-hospital cardiac arrest with a shockable rhythm; for non-shockable rhythm and in-hospital cardiac arrest, temperature control was suggested as a weak recommendation [7].

Click here to read the full article.

Read more...

Breaking news: Emergency Medicine Takes a New Turn in the Netherlands

On the 26 October 2023, we received the incredible news that the Dutch Society for Emergency Medicine (NVSHA) had received confirmation from the Ministry of Health that Emergency Medicine has been officially recognised as a primary specialty in the Netherlands.

This achievement has come about as a result of the hard work of NVSHA and its leadership over a sustained period of some 25 years.

EUSEM warmly congratulates the NVSHA on this remarkable achievement, which will undoubtedly bring tremendous benefits to the entire healthcare system and emergency medicine doctors in the Netherlands. 

As a society whose aim is to achieve the recognition of Emergency Medicine as a specialty across Europe we feel honoured to have the NVSHA as a member and thank NVSHA for their work. We look forward to continued collaborative work to make Emergency Medicine in Europe the best it can be.

Click HERE to read the full article in Dutch 

 

 

 

Read more...

New publication: Status of the specialty Emergency Medicine in Europe

By Wilhelm Behringer (a) and Ruth Brown (b)

aDepartment of Emergency Medicine, Medical University of Vienna, Austria and and bImperial College Healthcare NHS trust, UK
Correspondence to Wilhelm Behringer, MD, MBA, MSc, Department of Emergency Medicine, Medical University Vienna, Vienna General Hospital

Received 28 July 2023 Accepted 29 July 2023.

Extract

Emergency Medicine is a relatively young specialty in Europe [1,2]. It started in Europe 1972, when the first 30 consultant posts were established in the UK, at that time under the name Accident & Emergency medicine, which was changed to Emergency Medicine in 2004 [3]. The European Union of Medical Specialists (Union Européenne des Médecins Spécialistes, UEMS) represents hospital medical specialists within the member states of the EU, and includes 43 specialist sections representing independently recognized specialties. Continue reading....

 

Read more...

PRESS RELEASE Identifying sepsis: only two out of four recommended screening tools are useful Paramedics and emergency doctors almost never suspect sepsis

Embargo: 00.01 hrs CEST on Wednesday 20 September 2023

Barcelona, Spain: Two out of the four internationally-recommended screening tools used by emergency medical services are inadequate for recognising sepsis, according to new research presented at the European Emergency Medicine Congress today (Wednesday).

Mrs Silke Piedmont, a health scientist at the Department of Emergency Medicine Campus Benjamin Franklin Charité – Universitätsmedizin Berlin (Germany), and her colleagues from the University of Magdeburg and Jena (Germany), analysed data on 221,429 patients who were seen by emergency medical services (EMS) in Germany in 2016 outside of the hospital setting. They found that only one out of four screening tools had a reasonably accurate prediction rate for sepsis – NEWS-2 (National Early Warning Score). It was able to correctly predict 72.2% of all sepsis cases and correctly identified 81.4% of negative, non-septic, cases.

A second screening tool, qSOFA (quick Sequential Organ Failure Assessment), correctly predicted 96.6% of patients who did not have sepsis.

Mrs Piedmont said: “We found that paramedics never documented a suspicion of sepsis, and emergency services physicians rarely did so, only documenting a suspicion in 0.1% of cases. The screening tools recommended in the Surviving Sepsis Campaign guidelines differed greatly in terms of which and how many patients were identified as possibly having sepsis.”  

Sepsis, often referred to as blood poisoning, is a life-threatening condition that arises when the body’s immune system goes into overdrive in response to an infection and injures the body’s tissues and organs. It is vital to recognise it early, otherwise it can lead to shock, multiple organ failure and even death.

Speaking before the Congress, her colleague Dr Wolfgang Bauer, senior physician at the Charité, said: “In emergency care, there are good and long-established standards for the detection and treatment of heart attacks and stroke that have improved patients’ chances of survival. Unfortunately, a lot less attention is paid to sepsis and standards to improve early sepsis recognition and survival. Our study found there was a similar incidence for sepsis, 1.6%, as for heart attacks, 2.6%, and stroke, 2.7%, in cases seen by emergency medical services. However, in terms of both percentages and absolute numbers, more patients died from sepsis than from heart attacks or stroke. Out of all cases with sepsis, 31.4% died within 30 days after being seen by emergency services, versus 13.4% and 11.8% respectively for heart attacks and stroke. These findings emphasise the need for better sepsis awareness and more frequent use of effective screening tools.”

Mrs Piedmont and colleagues say the Surviving Sepsis Campaign guidelines about which sepsis screening tool is the most reliable for use by EMS are not specific enough and are based on little, useful evidence. The aim of the current study was to assess which of four screening tools was best for EMS to predict sepsis – NEWS-2, MEWS (Modified Early Warning Score), SIRS (Systemic Inflammatory Response Syndrome) or qSOFA.

The study linked data on 221,429 cases with follow-up between 2016 and 2017 from ten health insurance companies with information from documentation by paramedics and emergency doctors on 110,419 cases in 2016. This enabled the researchers to calculate the four screening tools’ ability to predict that a patient had sepsis. The predictions were confirmed or rejected during subsequent hospital investigations after contact with EMS. The researchers also looked at incidence and death rates for sepsis compared to heart attack and stroke, how much was recorded about any suspicions of sepsis, and how often EMS staff would have documented sepsis if they had used screening tools.

When they compared the performance of the four screening tools, the researchers found that NEWS-2 was the best for identifying patients with sepsis as it had a sensitivity (correctly predicted sepsis) of 72.2%, followed by MEWS, which had a sensitivity of 46.8% and a specificity (correctly predicted no sepsis) of 88.4%, SIRS (30.4% sensitivity, 93.8% specificity), and qSOFA (24% sensitivity, 96.6% specificity). Out of all EMS cases, 24.3% of cases were predicted to have sepsis by at least one of the screening tools, but only 0.9% were predicted to have sepsis by all four tools simultaneously.

“The incidence and death rates for sepsis and the low recognition of it, emphasise the need for better awareness and more frequent use of screening tools,” said Mrs Piedmont. “No screening tool provides ideal performance. NEWS-2 best supports emergency medical services in identifying most patients with sepsis. EMS patients that are NEWS-2 positive should be flagged up as potentially having sepsis and referred for special attention and assessment by emergency doctors who are expert in sepsis. If EMS insist on using the qSOFA, they should be aware that a positive qSOFA makes sepsis likely, but also, that a negative qSOFA cannot rule out sepsis conclusively.

“A rule of thumb for EMS staff could be that NEWS-2 negative patients are the most likely not to have sepsis, and qSOFA positive patients are the most likely to have sepsis – and also that qSOFA misses many patients with sepsis. Further clinical patient assessment and evaluation will always be needed for both tools. Future sepsis guidelines should be more precise and omit recommendations for MEWS and SIRS for emergency medical services since they were inferior in all the measures for accuracy.”

The researchers say these findings could also apply to other countries, especially as studies in Canada and the UK support aspects of their results [2,3]. “Ours is the first study comparing all four screening tools and showing the predictive usefulness of applying the screening tools to all adult patients independently of any presumptions or preliminary diagnoses by emergency medical services,” said Mrs Piedmont.

There were two things that could be improved, say the researchers: better and complete assessments of vital signs, such as body temperature and breathing rate; and “translating” alarming vital signs into a suspicion of sepsis, which could be helped by using a good sepsis screening tool.

“Sepsis causes approximately 20% of all global deaths,” said Mrs Piedmont [4]. “There is great potential to save lives and maintain patients’ quality of life if sepsis is recognised and treated earlier. As most sepsis cases start outside of hospital, emergency medical services play a vital role. They can shorten the length of time until sepsis treatments can be provided quickly in hospitals and reduce the risk of dying if they suspect sepsis.

“In addition, it’s crucial that the public’s awareness of sepsis is increased, by integrating it into education systems and through media campaigns. Patients ought to know the variety of sepsis symptoms, how urgent it is to call for prompt help and to ask the question ‘Could it be sepsis?’. As sepsis prevention is even better than early detection, they should also be aware of preventive measures such as hygiene and vaccination.”

The researchers hope their findings will inform new guidelines on sepsis that are being drawn up in some countries so as to give more specific recommendations for sepsis screening. More research is also needed to improve screening tools and to assess the real-world effects of screening tools on patients with and without sepsis.

Professor Youri Yordanov from the St Antoine Hospital emergency department (APHP Paris), France, is Chair of the EUSEM 2023 abstract committee and was not involved in the research. He said: “Sadly, we too often see patients being brought into hospital emergency departments with advanced sepsis. Some of them we can save, but unfortunately some will die who could have been saved if they had received treatment at an earlier stage. Emergency services need tools that can help them quickly and accurately predict that a patient may have sepsis and should be investigated further in hospital. This study shows that more needs to be done to develop such tools and improve the existing ones. Only then will we be able to bring down the death rates from sepsis.”

(ends)

[1] Abstract no: OA97, “Sepsis screening by Emergency Medical Services - Why recommendations of the Surviving Sepsis Campaign are too unspecific. Results from a cohort study,” by Silke Piedmont, in the oral abstract session “Pre-hospital and EMS”, 10.35-12.00 hrs CEST, Wednesday 20 September in the VIP room.  https://shorturl.at/guwJR

[2] Lane DJ, Wunsch H, Saskin R, Cheskes S, Lin S, Morrison LJ, Scales DC. Screening strategies to identify sepsis in the prehospital setting: a validation study. CMAJ. 2020a;192:E230-E239. doi:10.1503/cmaj.190966.

[3] Scott LJ, Redmond NM, Garrett J, Whiting P, Northstone K, Pullyblank A. Distributions of the National Early Warning Score (NEWS) across a healthcare system following a large-scale roll-out. Emerg Med J. 2019;36:287–92. doi:10.1136/emermed-2018-208140.

[4] Rudd KE et al. Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease. Lancet 2020; 395: 200-11. doi: https://doi.org/10.1016/ S0140-6736(19)32989-7.

Note: When obtaining outside comment, journalists are requested to ensure that their contacts are aware of the embargo on this release.

 

Funding: The data were acquired as part of the project “Integrated emergency care: A focus on emergency medical services” (http://rettungsdienst-im-fokus.ovgu.de) which was funded by the German Innovation Fund of the Joint Federal Committee (G-BA) (funding identifier: 01VSF17032). The funder had no influence on the published results. All authors have no conflict of interest to declare.

 

About European Society of Emergency Medicine (EUSEM)

Read more...